Discriminatory Dissolution Testing for Liquisolid Compacts Containing a Poorly Water-Soluble Drug (Hydrochlorothiazide)

Liquisolid Compacts: An Effective Approach towards Enhancement of Dissolution Rate of Poorly Soluble Drugs

Department of pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. ______________________________________________________________________ ABSTRACT Poorly water-soluble drugs involve many difficulties in the development of pharmaceutical dosage forms for oral delivery systems due to their low bioavailability. Therapeutic effectiveness of a drug depends upon the bioavailabilit...

Enhancement of Dissolution Rate of Indomethacin Using Liquisolid Compacts

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...

Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective

The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and the agencies that regulate them. These challenges include developing and validating the test methods, ensuring that methods are appropriately discriminatory, and addressing the potential for an in vivo–in vitro correlation (IVIVC). Di...

Enhancement of Dissolution Rate of Indomethacin: Using Liquisolid Compacts

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib